Events
Centre Overview
Post-Doctoral Fellow
- Ph.D candidates in Biomedical Sciences, Biological Sciences, or a related discipline, are invited to submit their application to start career development in the following aspects: stem cells, regenerative medicine, animal models, immunology, embryology, genomics, genome-editing or drug screening
Postgraduate Student
- Bachelor’s or Master's degree graduates in Biomedical Sciences, Biological Sciences, or a related discipline who are interested in taking a MPhil or PhD study in one of the research areas including stem cells, regenerative medicine, cancaer, immunology, embryology or genomics medicine are welcome to approach us for more information
Research Assistant / Research Associate
- Bachelor’s / Master's degree candidates in Biomedical Sciences, Biological Sciences, or a related discipline, who are interested in joining the multidisciplinary team with academic scientists and clinicians are welcome
Laboratory Manager
- Applicants should have a Master’s degree or above in science or related disciplines, with at least 5 years’ research experience in laboratory, prefer at least 2 years of laboratory management
- Excellent communication, organizational and laboratory skills and knowledge of laboratory safety procedures is highly preferred
- Experience in the following areas would be an advantage, stem cell culture, iPSC, EPSC, transfection, crispr cloning, molecular biology, protein related experiment, histology, microscopy and next generation sequencing
Assistant IT Manager / IT Officer
- Applicants should possess a bachelor's degree or above in computer science, information engineering, or related disciplines, with at least 3 years' of working experience in information technology
- They should have substantial experience in full stack application development, Microsoft 365, server consolidation, virtualization, containerization, installation, troubleshooting and administration of network attached storage (NAS) High Availability Cluster
- Experience in website/ intranet design and maintenance are preferred
Part-Time Executive Assistant
- Applicants should have a diploma or above in accounting or related disciplines, with at least 1 year accounting/executive assistant/personal assistant or similar working experience
- They should have substantial experience in full stack application development, Microsoft 365, server consolidation, virtualization, containerization, installation, troubleshooting and administration of network attached storage (NAS) High Availability Cluster
- They should have a good command of written and spoke English (including Mandarin), excellent MS Office knowledge, outstanding organizational and time management skills, familiarity with office gadgets and applications (such as e-calendars, copy machines etc.), and have strict attitude towards discretion and confidentiality
Centre for Translational Stem Cell Biology (CTSCB) aims to develop world-leading new technologies in Hong Kong and to apply them to regenerative medicine, autoimmunity and genomic medicine under the golden age of research. By bringing together world-leading scientists and clinicians from Hong Kong, UK and other international collaborators who are studying stem cells and genomics, CTSCB strives to translate their discoveries into both commercial successes and healthcare benefits.
All the CTSCB researches come from the state-of-the-art technology, the Expanded Potential stem Cells (EPSC), which is initially developed by Centre Director Professor Pengtao Liu’s laboratory at the Wellcome Trust Sanger Institute in collaboration with the University of Cambridge, and more recently at The University of Hong Kong. Under the leadership by the group of elite scientists and clinicians, CTSCB is going to achieve two major objectives in clinical, translational and fundamental research during the three interconnected research programmes.
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Publication
- Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
- Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
- Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
- Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
- Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
- Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
- Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
- Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090
Publication
- Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
- CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312. https://doi.org/10.1016/j.yexcr.2017.02.017
- Lee JC, Biasci D, Roberts R… Mansfield Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268. https://doi.org/10.1038/ng.3755
- Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484. https://doi.org/10.1038/cr.2017.127
- IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212. http://dx.doi.org/10.1016/j.canlet.2018.05.044
- Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
- Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
- Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148
- Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
- Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013