Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013
EPSCs for Regenerative Medicine & Human Disease Study

Clinical grade human EPSC-MSCs will first undergo extensive pre-clinical evaluation for safety and efficacy for transplantation in our established clinically relevant large animal models of heart diseases.

  • Application of stem cell-derived cells for disease modeling/drug screening
  • Cell products
  • EPSCs as platform for the generation of genome-edited animals
Project Team Members

Prof. Hung Fat TSE

Programme Leader
Vision care, Dress shirt, Glasses, Chin, Sleeve, Eyewear, Collar

Prof. Pengtao Liu

Principal Investigator
Dress shirt, Forehead, Chin, Eyebrow, Gesture, Finger

Prof. William YEUNG

Principal Investigator
Cheek, Smile, Lip, Chin, Shoulder, Eyebrow, Neck, Jaw, Sleeve, Eyelash

Dr. Cherie LEE

Principal Investigator
Street fashion, Dress shirt, Flash photography, Face, Smile, Leg, Neck, Sleeve, Standing, Waist

Dr. Stephanie MA

Principal Investigator
Forehead, Nose, Hair, Smile, Eyebrow, Eye, Mouth, Jaw, Neck, Happy

Dr. Fotios SAMPAZIOTIS

Principal Investigator
Vision care, Polo shirt, Flash photography, Glasses, Watch, Joint, Shoulder, Neck, Sleeve

Dr. Rio SUGIMURA

Principal Investigator
Vision care, Forehead, Hair, Nose, Glasses, Cheek, Smile, Skin, Chin, Eyebrow

Dr. Guocheng LAN

Principal Researcher

Dr. Kwong Man NG

Scientific Officer (HKU)

Tony LI

Senior Technical Manager (HKU)

Dr. Claire WEI

Post-Doctoral Fellow

Dr. Yangyang YUAN

Post-Doctoral Fellow

Kenso SO

Senior Technical Officer

Jenny CHAN

MPhil Student

Vivian CHU

Research Assistant

Jacob DING

Research Assistant

Kyle LEE

Research Associate

Cheyenne MA

PhD Student
Vision care, Dress shirt, Forehead, Face, Glasses, Chin, Eyebrow, Eye, Tie, Neck

Timothy Chun Hin WONG

Reserach Assistant

Yuqing ZHAI

PhD Student

Shao XU

Research Assistant

Shihui ZHANG

Research Assistant
Selected Publication
  1. Yue C, Chen ACH, Tian S… Yeung WSB, Lee YL. (2020) Human embryonic stem cell–derived blastocyst-like spheroids resemble human trophectoderm during early implantation process. Fertil Steril 114(3): 653-664. https://doi.org/10.1016/j.fertnstert.2020.01.009
  2. Ohta R*, Sugimura R*, Niwa A, Saito MK. (2019) Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-Free Defined Condition. (*co-first author) J Vis Exp JoVE 148.  https://doi.org/10.3791/59823
  3. Yang J, Ryan DJ, Lan G, Zou X, Liu P. (2019) In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells. Nature Protocols, 14: 350-378. http://dx.doi.org/10.1038/s41596-018-0096-4
  4. Chan LH, Zhou L, Ng KY… Huen MS, Ma S. (2018) Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation. Cell Rep 25:690-701. http://dx.doi.org/10.1016/j.celrep.2018.09.053
  5. Segeritz CP, Rashid ST, Cardoso de Brito M… Lomas DA*, Vallier L*. (2018) hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.) J Hepatol. 69(4): 851-860. (*joint authorship) https://doi.org/10.1016/j.jhep.2018.05.028
  6. Sampaziotis F, Justin AW, Tysoe OC… Saeb-Parsy K*, Vallier L*. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23(8): 954-963. (*joint authorship) https://doi.org/10.1038/nm.4360
  7. Yang J, Wang Y, Zhou T… Esteban MA, Tse HF. (2017) Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports 8:603-618. https://doi.org/10.1016/j.stemcr.2017.01.027
  8. Lee YL, Fong SW, Chen AC… Yeung WS, Lee KF. (2015) Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod. 30 (11):2614-26.  http://dx.doi.org/10.1093/humrep/dev223

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