Official Collaborated with:
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EPSCs for Regenerative Medicine & Human Disease Study
Clinical grade human EPSC-MSCs will first undergo extensive pre-clinical evaluation for safety and efficacy for transplantation in our established clinically relevant large animal models of heart diseases.
- Application of stem cell-derived cells for disease modeling/drug screening
- Cell products
- EPSCs as platform for the generation of genome-edited animals
Project Team Members
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Professor Hung Fat TSE
Programme Leader
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Dr. Fotios SAMPAZIOTIS
Programme Co-Leader
![Vision care, Dress shirt, Glasses, Chin, Sleeve, Eyewear, Collar](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82/private/uG6SJvH3ihMapKtkQ6kSjoTU4tk2/image/78NnnrKaQs.jpeg)
Professor Pengtao Liu
Managing Director
![Street fashion, Dress shirt, Flash photography, Face, Smile, Leg, Neck, Sleeve, Standing, Waist](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/lqCeI-5nNG.jpg)
Professor Stephanie MA
Principal Investigator
![Dress shirt, White coat, Human body, Glasses, Smile, Workwear, Sleeve, Gesture, Collar](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/IGrn0f0Bul.jpg)
Professor William YEUNG
Principal Investigator
![White coat, Dress shirt, Human body, Smile, Arm, Shoulder, Eye, Neck, Sleeve](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/wVvj-YFRpJ.jpg)
Dr. Cherie LEE
Principal Investigator
![Vision care, Polo shirt, Flash photography, Glasses, Watch, Joint, Shoulder, Neck, Sleeve](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/wPWFiwQO05.jpg)
Dr. Rio SUGIMURA
Principal Investigator
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Dr. Guocheng LAN
Principal Researcher
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Dr. Kwong Man NG
Scientific Officer (HKU)
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Tony LI
Senior Technical Manager (HKU)
![Clothing, Hair, Chin, Eyebrow, Sleeve, Tie, Collar, Gesture](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/cEEn8pxFPF.png)
Dr. Nicole Tianqi LI
Post-Doctoral Fellow
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Dr. Hanzhang RUAN
Post-Doctoral Fellow
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Dr. Yangyang YUAN
Post-Doctoral Fellow
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Kenso SO
Senior Technical Officer
![Dress shirt, White coat, Fashion design, Shoulder, Neck, Sleeve, Gesture, Collar, Workwear](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/yujKdCjSgJ.jpg)
Jenny CHAN
MPhil Student
![Dress shirt, Human body, Outerwear, Coat, Neck, Sleeve, Gesture, Collar, Suit](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/7_IenTNR2M.jpg)
Xianjie HUANG
PhD Student
![Forehead, Nose, Cheek, Eyebrow, Jaw, Eyelash, Gesture](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/WSvvytvl2n.png)
Daniel LU
Research Assistant
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Kyle LEE
Research Associate
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Cheyenne MA
PhD Student
![Dress shirt, Face, Smile, Head, Jaw, Neck, Sleeve, Gesture, Collar](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,h=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/jK7XMFP27h.jpg)
Timothy Chun Hin WONG
Reserach Assistant
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Yuqing ZHAI
PhD Student
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Shao XU
Research Assistant
![Dress shirt, Hair, Lip, Chin, Eyebrow, Neck, Jaw, Sleeve, Gesture, Collar](https://cdn.vev.design/cdn-cgi/image/f=auto,q=82,w=1920/private/zmzK6Ph7KJVWPgx9pXENZ0kZOH33/image/5rFcVuZCz6.jpeg)
Anna Xiaoyi ZHANG
Research Assistant
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Shihui ZHANG
Research Assistant
Selected Publication
- Lee TK, Guan X, Ma SKY. (2021) Cancer stem cells in hepatocellular carcinoma: from origin to clinical implications. Nature Reviews Gastroenterology and Hepatology 9. https://doi.org/10.1038/s41575-021-00508-3
- Yue C, Chen ACH, Tian S… Yeung WSB, Lee YL. (2020) Human embryonic stem cell–derived blastocyst-like spheroids resemble human trophectoderm during early implantation process. Fertil Steril 114(3): 653-664. https://doi.org/10.1016/j.fertnstert.2020.01.009
- Ohta R*, Sugimura R*, Niwa A, Saito MK. (2019) Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-Free Defined Condition. (*co-first author) J Vis Exp JoVE 148. https://doi.org/10.3791/59823
- Yang J, Ryan DJ, Lan G, Zou X, Liu P. (2019) In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells. Nature Protocols, 14: 350-378. http://dx.doi.org/10.1038/s41596-018-0096-4
- Chan LH, Zhou L, Ng KY… Huen MS, Ma S. (2018) Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation. Cell Rep 25:690-701. http://dx.doi.org/10.1016/j.celrep.2018.09.053
- Segeritz CP, Rashid ST, Cardoso de Brito M… Lomas DA*, Vallier L*. (2018) hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in α1-antitrypsin deficiency.) J Hepatol. 69(4): 851-860. (*joint authorship) https://doi.org/10.1016/j.jhep.2018.05.028
- Sampaziotis F, Justin AW, Tysoe OC… Saeb-Parsy K*, Vallier L*. (2017) Reconstruction of the mouse extrahepatic biliary tree using primary human extrahepatic cholangiocyte organoids. Nature Medicine 23(8): 954-963. (*joint authorship) https://doi.org/10.1038/nm.4360
- Yang J, Wang Y, Zhou T… Esteban MA, Tse HF. (2017) Generation of Human Liver Chimeric Mice with Hepatocytes from Familial Hypercholesterolemia Induced Pluripotent Stem Cells. Stem Cell Reports 8:603-618. https://doi.org/10.1016/j.stemcr.2017.01.027
- Lee YL, Fong SW, Chen AC… Yeung WS, Lee KF. (2015) Establishment of a novel human embryonic stem cell-derived trophoblastic spheroid implantation model. Hum Reprod. 30 (11):2614-26. http://dx.doi.org/10.1093/humrep/dev223
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