Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Centre for Translational Stem Cell Biology  

幹細胞轉化研究中心

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Meet Our Team
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Professor Gordon DOUGAN

Co-Director

Expertise

Genetic Analysis of Host/Pathogen Interactions during Infection
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Professor Pengtao LIU

Managing Director & Programme Leader

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Expanded Potential Stem Cells (EPSCs), Totipotent and Pluripotent Stem Cells, Hematopoiesis and Immune Cell Functions

Professor Chak Sing LAU

Programme Leader

Expertise

Clinical Professor in Rheumatology & Clinical Immunology, Cellular Immune-dysregulation in Systemic Lupus Erythematosus, Autoimmune Disorders

Professor Hung Fat TSE

Programme Leader

Expertise

Clinical Professor in Cardiology, Cardiac Pacing and Electrophysiology, Stem Cells in Cardiovascular Regenerative Medicine, Treatment of Heart Rhythm Disorder

Professor Ken SMITH

Programme Leader

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Immune Regulation, Autoimmune Disease and Infection

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Professor Bertie GÖTTGENS

Programme Co-Leader

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Blood Cell Development, Mutations in Stem/Progenitor Cells causing Leukaemia

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Dr. Fotios SAMPAZIOTIS

Programme Co-Leader

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Hepatobiliary disorders

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Professor Stephanie Kwai Yee MA

Principal Investigator

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Cancer Biology, Tumorigenesis, Biological and Molecular Characteristics of Cancer Stem Cells, Liver Cancer, Drug Screening

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Professor William Shu Biu YEUNG

Principal Investigator

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Reproduction, Endometrial Stem Cells, Fertilizatioin, Embryonic Activities

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Dr. Vera Sau Fong CHAN

Principal Investigator

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C-type Lectin Receptors Immunobiology, Systemic Lupus Erythematosus, Autoimmune Diseases Pathogenesis Study

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Dr. Bo GAO

Principal Investigator

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Cell Signaling in Development and Disease, Human Genetics and Developmental Genetics, WnT/PCP Signaling, Genetic Skeletal Disorder

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Dr. Yuanhua HUANG

Principal Investigator

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Single Cell Data Science, Bioinformatics, Somatic Mutations, Computational Algorithms for Biomedical Data Analysis

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Dr. Ralf JAUCH

Principal Investigator

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Protein Engineering, Cellular Reprogramming, Transcription Factor (TF) Mediated Cell Fate Conversions, Deep Sequencing

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Dr. Cherie Yin Lau LEE

Principal Investigator

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Human Embryonic Stem Cells, Epigenetic Regulation of Pluripotent Stem Cells, Reprogramming of Induced Pluripotent Stem Cells

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Dr. Philip Hei LI

Principal Investigator

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Clinicial Specialist in Immunology & Allergy, Anaphylaxis, Drug Hypersensitivity and Immunodeficiency, Adult Immunodeficiency Syndromes

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Dr. Rio Ryohichi SUGIMURA

Principal Investigator

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CAR-T, Single-Cell RNA Sequencing, Spatial Transcriptomics, Stem Cell Differentiation, Organoids, Hematopoiesis&Immunology, Cancer Immunotherapy

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Professor Menna CLATWORTHY

Principal Investigator

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Human Tissue Immunity

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Dr. María DUQUE-CORREA

Principal Investigator

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Infectious Diseases, Host-Pathogen Interaction and Immunology

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Dr. María Duque-Correa

Principal Investigator

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Infectious Diseases, Host-Pathogen Interaction and Immunology

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Dr. María Duque-Correa

Principal Investigator

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Infectious Diseases, Host-Pathogen Interaction and Immunology

Scientific & Research Team
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Professor Fang LIU

Senior Scientific Director
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Dr. Hui LIU

Head of Technology (Antibody)
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Dr. Dominik SPENSBERGER

Head of Technology (Genome Engineering)
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Dr. Dirk ZAHN

Head of Technology (Single-Domain Antibody)
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Dr. Guocheng LAN

Principal Researcher
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Dr. Degong RUAN

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Dr. Melania BARILE

Post-Doctoral Fellow
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Dr. Zhen FENG

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Dr. Jilong GUO

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Dr. Yingzhang HUANG

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Dr. Nicole Tianqi LI

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Dr. Qingqing LIU

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Dr. Xueyan LIU

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Dr. Luyao MA

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Dr. April Thi Thuy NGUYEN

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Dr. Hanzhang RUAN

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Dr. Yangyang YUAN

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Dr. Weiyu ZHANG

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Dr. Kwong Man NG

Scientfic Officer (HKU)

Tony Chung LI

Senior Technical Manager
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Dr. Guoliang WANG

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Jenny Lok Man CHAN

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Yiming CHAO

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Chen CHENG

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Xianjie HUANG

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Daniel LU

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Cheyenne Chui Yan MA

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Tony Yuebin TAN

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Wendy Cheuk Ying TIU

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Faria Tin Wai TSUI

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Timothy Chun Hin WONG

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Dr. Andy Chun Hang CHAN

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Post-Doctoral Fellow
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