Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013
Meet Our Team
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Professor Gordon DOUGAN

Deputy Director

Expertise

Genetic Analysis of Host/Pathogen Interactions during Infection
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Professor Pengtao LIU

Managing Director & Programme Leader

Expertise

Expanded Potential Stem Cells (EPSCs), Totipotent and Pluripotent Stem Cells, Hematopoiesis and Immune Cell Functions

Professor Chak Sing LAU

Programme Leader

Expertise

Clinical Professor in Rheumatology & Clinical Immunology, Cellular Immune-dysregulation in Systemic Lupus Erythematosus, Autoimmune Disorders

Professor Hung Fat TSE

Programme Leader

Expertise

Clinical Professor in Cardiology, Cardiac Pacing and Electrophysiology, Stem Cells in Cardiovascular Regenerative Medicine, Treatment of Heart Rhythm Disorder

Professor Ken SMITH

Programme Leader

Expertise

Immune Regulation, Autoimmune Disease and Infection

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Professor William Shu Biu YEUNG

Principal Investigator

Expertise

Reproduction, Endometrial Stem Cells, Fertilizatioin, Embryonic Activities

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Dr. Bo GAO

Principal Investigator

Expertise

Cell Signaling in Development and Disease, Human Genetics and Developmental Genetics, WnT/PCP Signaling, Genetic Skeletal Disorder

Dr. Vera Sau Fong CHAN

Principal Investigator

Expertise

C-type Lectin Receptors Immunobiology, Systemic Lupus Erythematosus, Autoimmune Diseases Pathogenesis Study

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Dr. Yuanhua HUANG

Principal Investigator

Expertise

Single Cell Data Science, Bioinformatics, Somatic Mutations, Computational Algorithms for Biomedical Data Analysis

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Dr. Ralf JAUCH

Principal Investigator

Expertise

Protein Engineering, Cellular Reprogramming, Transcription Factor (TF) Mediated Cell Fate Conversions, Deep Sequencing

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Dr. Cherie Yin Lau LEE

Principal Investigator

Expertise

Human Embryonic Stem Cells, Epigenetic Regulation of Pluripotent Stem Cells, Reprogramming of Induced Pluripotent Stem Cells

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Dr. Philip Hei LI

Principal Investigator

Expertise

Clinicial Specialist in Immunology & Allergy, Anaphylaxis, Drug Hypersensitivity and Immunodeficiency, Adult Immunodeficiency Syndromes

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Dr. Stephanie Kwai Yee MA

Principal Investigator

Expertise

Cancer Biology, Tumorigenesis, Biological and Molecular Characteristics of Cancer Stem Cells, Liver Cancer, Drug Screening

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Dr. Rio Ryohichi SUGIMURA

Principal Investigator

Expertise

CAR-T, Single-Cell RNA Sequencing, Spatial Transcriptomics, Stem Cell Differentiation, Organoids, Hematopoiesis&Immunology, Cancer Immunotherapy

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Professor Bertie GÖTTGENS

Principal Investigator

Expertise

Blood Cell Development, Mutations in Stem/Progenitor Cells causing Leukaemia

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Professor Menna CLATWORTHY

Principal Investigator

Expertise

Human Tissue Immunity

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Dr. María DUQUE-CORREA

Principal Investigator

Expertise

Infectious Diseases, Host-Pathogen Interaction and Immunology

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Dr. Fotios SAMPAZIOTIS

Principal Investigator

Expertise

Hepatobiliary disorders

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Dr. María Duque-Correa

Principal Investigator

Expertise

Infectious Diseases, Host-Pathogen Interaction and Immunology

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Dr. María Duque-Correa

Principal Investigator

Expertise

Infectious Diseases, Host-Pathogen Interaction and Immunology

Research Team
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Dr. Guocheng LAN

Principal Researcher

Dr. Melania BARILE

Post-Doctoral Fellow

Dr. Handi CAO

Post-Doctoral Fellow
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Dr. Zhen FENG

Post-Doctoral Fellow
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Dr. Ricky Wai Kiu LAU

Post-Doctoral Fellow
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Dr. Xueyan LIU

Post-Doctoral Fellow

Dr. Chang MING

Post-Doctoral Fellow

Dr. Degong RUAN

Research Associate
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Dr. Yuan WANG

Post-Doctoral Fellow

Dr. Yangyang YUAN

Post-Doctoral Fellow

Dr. Weiyu ZHANG

Post-Doctoral Fellow

Dr. Kwong Man NG

Scientfic Officer (HKU)

Tony Chung LI

Senior Technical Manager

Jenny Lok Man CHAN

MPhil Student

Yiming CHAO

PhD Student

Chen CHENG

MPhil Student

Vivian Wai Yan CHU

Research Assistant

Ziwei HE

PhD Student

Cindy Xinning HU

MPhil Student

Xianjie HUANG

PhD Student
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Wenxin JIANG

Research Assistant
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Danny LI

Research Assistant

Cheyenne Chui Yan MA

PhD Student

Chung Sze OR

PhD Student

Tony Yuebin TAN

PhD Student
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Faria Tin Wai TSUI

Research Assistant
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Timothy Chun Hin WONG

Research Assistant

Jack Jian WU

Research Assistant
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Shijia XIA

Research Assistant

Shao XU

Research Assistant
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Claire Woojeong YANG

Research Assistant

Sophronia Ming Tsun YIP

Research Assistant

Yuqing ZHAI

PhD Student

Shihui ZHANG

PhD Student
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Ri Min TAN

Student Research Assistant

Dr. Andy Chun Hang CHAN

Honorary Research Associate

Dr. Mehran RAHMANI

Post-Doctoral Fellow
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Dr. Derek Hoi Hang HO

Honorary Research Associate
Administration Team
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Professor Fang LIU

Senior Scientific Director

Angel LEE

Assistant Director

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Karen CHAN

Executive Officer (Finance)

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Maggie KWONG

Executive Officer (HR)

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Lab Man

Laboratory Manager

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