Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

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Our Research

We translate discoveries into innovative solutions and therapies.

From Bench to Business



Our spin-offs take EPSC technology from the bench directly to market.




Building an EPSC Spin-off Ecosystem

We connect EPSC technology with industry partners, investors, and innovators to turn breakthroughs into products and services that change lives.

Our spin-offs are active across genome editing, antiviral drug discovery, immuno-oncology, skincare, and scalable cell manufacturing. This is what’s possible when science meets translation.

Our Innovative Spinoffs

is a biotechnology company specializing in science-driven skincare and cosmeceutical innovation through its proprietary ingredient, STEM ELIXIR.
pioneers the development of GMP-grade mesenchymal stem cells (MSCs) derived from EPSCs, offering a sustainable and scalable alternative to umbilical cord-based MSCs.
is at the forefront of next-generation immuno-oncology, pioneering CAR-macrophage (CAR-M) therapies specifically designed to target solid tumors. Our primary focus is on liver cancer (HCC) patients who are resistant to current treatment.
accelerates antiviral innovation through its proprietary placenta-like stem cell platform, enabling rapid and accurate discovery of novel antiviral candidates and development of effective antiviral drugs and health products.
is revolutionizing stem cell research by advancing EPSC technologies. Our expertise includes the derivation of superior EPSC lines, manufacturing premium EPSC culture media.
specializes in cutting-edge genome editing for mice models. We collaborate with academic institutions and pharmaceutical companies to deliver genetically engineered mice and cell lines, accelerating translational research and drug discovery.

Our Spin-offs

Estelle Biovita
Develops skincare powered by proprietary bioactive ingredients. Their flagship STEM ELIXIR line bridges biotechnology and beauty to deliver science-backed formulations.
Lucio Biotech
Produces GMP-grade mesenchymal stem cells (MSCs) derived from EPSCs. Their scalable, sustainable platform offers a consistent alternative to umbilical cord-based MSCs for regenerative medicine.
Synhealer
Develops Antibody-CAR-Macrophage (AB-CAR-M) therapies with dual targeting against solid tumors in patients resistant to current treatments. Their lead program focuses on hepatocellular carcinoma (HCC), a high-unmet-need indication.
Trophy Life Tech Co.
Leverages a proprietary placenta-like stem cell platform to accelerate the discovery of next-generation antiviral drugs and health solutions.
Expo Biotech
Advances stem cell research with superior cell lines and premium culture media. Their tools give researchers and biotech developers a stronger foundation for stem cell applications.
Genome Technology
Specializes in precision genome editing for mouse models, delivering custom genetically engineered mice and cell lines.
MabGenix
Develops fully human antibodies through two complementary platforms: a Transgenic Mouse platform that generates high-affinity antibodies by replacing murine immune genes with human sequences, and an AI platform that rapidly screens and prioritizes top candidates.

Our Spin-offs

Estelle Biovita
Develops skincare powered by proprietary bioactive ingredients. Their flagship STEM ELIXIR line bridges biotechnology and beauty to deliver science-backed formulations.
Lucio Biotech
Produces GMP-grade mesenchymal stem cells (MSCs) derived from EPSCs. Their scalable, sustainable platform offers a consistent alternative to umbilical cord-based MSCs for regenerative medicine.
Synhealer
Develops Antibody-CAR-Macrophage (AB-CAR-M) therapies with dual targeting against solid tumors in patients resistant to current treatments. Their lead program focuses on hepatocellular carcinoma (HCC), a high-unmet-need indication.
Trophy Life Tech Co.
Leverages a proprietary placenta-like stem cell platform to accelerate the discovery of next-generation antiviral drugs and health solutions.
Expo Biotech
Advances stem cell research with superior cell lines and premium culture media. Their tools give researchers and biotech developers a stronger foundation for stem cell applications.
Genome Technology
Specializes in precision genome editing for mouse models, delivering custom genetically engineered mice and cell lines.
MabGenix
Develops fully human antibodies through two complementary platforms: a Transgenic Mouse platform that generates high-affinity antibodies by replacing murine immune genes with human sequences, and an AI platform that rapidly screens and prioritizes top candidates.

Move Science Forward

We are driving future growth through an expanding portfolio of innovative spin-off companies, strengthening our global network and collaborative impact.

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Partner with us for custom solutions.

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