Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Official Collaborated with:

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Green and blue abstract yin-yang like logo with text 'Centre for Translational Stem Cell Biology' and its Chinese translation.

Newly Published:

November 14, 2024

Professor Ralf Jauch and his team published a paper titled "The emergence of Sox and POU transcription factors predates the origins of animal stem cells" in Nature Communications.  The project was led by HKU PhD graduates Dr. Ya Gao and Dr. Daisylyn Tan (Business Development Officer at CTSCB).

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CTSCB and WEHI Forge Strategic Research Partnership

October 18, 2024

On October 18, 2024, CTSCB and the Walter and Eliza Hall Institute of Medical Research (WEHI), a leading Australian medical research institute, officially signed a Memorandum of Understanding (MoU) to establish a strategic partnership.

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This collaboration marks a significant milestone in the fields of clinical immunology and cell biology. It aims to strengthen research capabilities, promote knowledge exchange, and accelerate talent development across both institutions. Under this MoU, CTSCB and WEHI will jointly explore diverse business opportunities and potential research collaborations, with a focus on pioneering medical research in immunology and cell biology.

Newly Published:

August 9, 2024

Professor Yuanhua Huang and his team from CTSCB and HKU published a paper titled "Robust analysis of allele-specific copy number alterations from scRNA-seq data with XClone"in nature communications.

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CTSCB wins 3 awards at 2024 Silicon Valley International Inventions Festival

July 28, 2024

CTSCB had a remarkable showing at the 2024 Silicon Valley International Inventions Festival (SVIIF), bringing home 2 gold medals and 1 silver medal for their innovative inventions in anti-viral, anti-ageing, and precision medicine.

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July 28 - Led by Professor Pengtao Liu, the CTSCB team won the gold medal for the innovative project “A Novel Stem Cell-Based Technology for Anti-viral Discovery and Health Natural Products.” The technology introduces a human EPSC-derived trophoblast model, which serves as an ideal system for virology research of diverse viruses and the discovery of potentially broad-spectrum antivirals.

The centre also captured a second gold medal for the pioneering project “A Novel Cellular System for Anti-ageing Drug Discovery.” The invention introduces an ageing-emulated biosystem derived from human trophoblast stem cells. The biosystem displays major ageing hallmarks and establishes an accelerated ageing model. This robust tool holds promise for advancing the understanding of ageing, expediting the development of anti-ageing, and improving human health and longevity.

In addition to the two gold medals, the CTSCB team secured a silver medal for the project” A New Stem Cell Platform for personalized treatment and drug discovery for primary immunodeficiency patients.”, which enables personalized treatment selection and new drug screening.

CTSCB will continue to transform our novel stem cell research innovations into real-world applications.

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CTSCB wins two gold medals and one silver at this year's Silicon Valley International Inventions Festival.

Photo showed Dr. RUAN Degong receives the gold medal.

June 27, 2024

CTSCB Unveils Groundbreaking Cellular System for Rapid Anti-Ageing Molecule Discovery

CTSCB has developed the world's first cellular system that can be used to rapidly discover molecules for anti-ageing. This pioneering invention has opened new frontiers in studying and understanding ageing mechanisms.

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Exciting Collaborations with AstraZeneca

May 16, 2024

CTSCB and AstraZeneca signed a Memorandum of Understanding (MoU) at the Asia Summit on Global Health. 

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May 16 - CTSCB and AstraZeneca signed a Memorandum of Understanding (MoU) at the Asia Summit on Global Health.  The ceremony was officiated by Professor Pengtao Liu (Managing Director, CTSCB) and Ms. Elise Ho (Business Unit Director, RIG, Macau and Alliance, AstraZeneca).

The signing of the MoU was witnessed by Mr. Lee Kwok Bun Ivan, JP, Commissioner for Innovation and Technology (ITC), Dr. Patrick Lau, Deputy Executive Director of the Hong Kong Trade Development Council (HKTDC), along with Professor Gordon Dougan (Co-director, CTSCB), Professor Chak-sing Lau (Dean of Medicine, HKU and Programme Leader, CTSCB), Professor Fang Liu (Senior Scientific Director, CTSCB) and Ms. Shan Wu (General Manager, AstraZeneca Hong Kong and Macau).

This MoU solidifies the long-standing partnership between CTSCB and AstraZeneca, and provides a framework for continued collaboration to foster innovation in stem cell translational clinical application.

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Photo shows the Commissioner for Innovation and Technology, Mr. Lee Kwok Bun Ivan, JP, (second row, 3rd right), Deputy Executive Director of the Hong Kong Trade Development Council, Dr. Patrick Lau (second row, 2nd right) with Professor Pengtao Liu (front row, right), Ms. Elise Ho (front row, left), Professor Gordon Dougan (second row, 1st right), Professor Chak-sing Lau (second row, 2nd left), Professor Fang Liu (second row, 1st left) and Ms. Shan Wu (second row, 3rd left) at the Mou Signing Ceremony.

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Commissioner for Innovation and Technology, Mr. Lee Kwok Bun Ivan, JP and Deputy Executive Director of the Hong Kong Trade Development Council, Dr. Patrick Lau visit our booth at the Asia Summit on Global Health.

Advancing Single-Cell Genomics through Partnership with MGI

May 14, 2024

On May 14, 2024, CTSCB signed a Memorandum of Understanding (MoU) with MGI International Sales Co., Ltd, which is a subsidiary of MGI Tech Co. Ltd. (MGI), to foster deeper collaboration!

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The signing ceremony was officiated by Professor Pengtao Liu (Managing Director, CTSCB), Professor Gordon Dougan (Co-director, CTSCB), and Mr. Vincent Lin (Director of BD center, MGI).

This collaboration between CTSCB and MGI marks an exciting milestone in the advancement of single cell technology. By combining MGI's cutting-edge sequencing platforms with the expertise of the CTSCB in stem cell research, the strategic partnership is poised to unlock new insights into cell identity, cellular heterogeneity and disease mechanisms.

“Together, we aim to revolutionize the field of single cell genomics and drive scientific discoveries that will ultimately improve human health,” said Professor Pengtao Liu.

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Photo shows Professor Pengtao Liu (front row, Left), Mr. Vincent Lam (front row, right), Professor Gordon Dougan (second row, 3rd right) with representatives from MGI

May 11, 2024

Advancing Cancer Immunotherapy Efficacy:

A Robust Cell Generation Platform

A joint research team from CTSCB and LKS Faculty of Medicine, the University of Hong Kong (HKUMed), and The Hong Kong University of Science and Technology (HKUST) has used stem cells to generate human immune cells for application in cancer immunotherapy.

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April 19, 2024

CTSCB wins Gold Medal in the 49th International Exhibition of Inventions of Geneva

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Representing CTSCB, Dr. Zhen Feng, Postdoctoral Fellow of the Anti-Ageing Project, Wenxin Jiang and Yoyo Li, together with Angel Lee, Centre manager, won a Gold Medal in the 49th International Exhibition of Inventions of Geneva.

April 17, 2024

Revolutionary Study Advances Personalized Treatment for Rare Immunodeficiency Patients

A collaborative research team, led by Professor Philip Li, Professor Pengtao Liu, and Professor Chak-sing Lau has developed a pioneering stem cell model that personalise treatment for patients with rare immunodeficiency.

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Newly Published:

April 16, 2024

Professor Rio Sugimura and his team from CTSCB and HKU published a paper titled "SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids" in Scientific Reports

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Newly Published:

March 20, 2024

Dr. Degong Ruan, CTSCB Research Scientist published his paper in Nature Protocols

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March 8, 2024

An innovative method to generate brain stem cells for age-related diseases

Congratulations to Professor Ralf Jauch and his team for developing an innovative method to transform blood and skin cells into neural stem cell. This achievement overcomes the limitations of current stem cell research techniques while opening up new possibilities for studying and working towards treatments for age-related diseases.

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