Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Official Collaborated with:

May 11, 2024

Advancing Cancer Immunotherapy Efficacy:

A Robust Cell Generation Platform

A joint research team from CTSCB and LKS Faculty of Medicine, the University of Hong Kong (HKUMed), and The Hong Kong University of Science and Technology (HKUST) has used stem cells to generate human immune cells for application in cancer immunotherapy.

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April 19, 2024

CTSCB wins Gold Medal in the 49th International Exhibition of Inventions of Geneva

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Representing CTSCB, Dr. Zhen Feng, Postdoctoral Fellow of the Anti-Ageing Project, Wenxin Jiang and Yoyo Li, together with Angel Lee, Centre manager, won a Gold Medal in the 49th International Exhibition of Inventions of Geneva.

April 17, 2024

Revolutionary Study Advances Personalized Treatment for Rare Immunodeficiency Patients

A collaborative research team, led by Professor Philip Li, Professor Pengtao Liu, and Professor Chak-sing Lau has developed a pioneering stem cell model that personalise treatment for patients with rare immunodeficiency.

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Newly Published:

April 16, 2024

Professor Rio Sugimura and his team from CTSCB and HKU published a paper titled "SARS-CoV-2 infection activates inflammatory macrophages in vascular immune organoids" in Scientific Reports

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Newly Published:

March 20, 2024

Dr. Degong Ruan, CTSCB Research Scientist published his paper in Nature Protocols

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March 8, 2024

An innovative method to generate brain stem cells for age-related diseases

Congratulations to Professor Ralf Jauch and his team for developing an innovative method to transform blood and skin cells into neural stem cell. This achievement overcomes the limitations of current stem cell research techniques while opening up new possibilities for studying and working towards treatments for age-related diseases.

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December 6, 2023

InnoHK Summit 2023

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Professor Pengtao Liu, Managing Director of CTSCB, and Professor Gordon Dougan, Co-Director of CTSCB were invited to deliver a speech at the InnoHK Summit 2023. 

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December 6 - The InnoHK Summit 2023, organized by the Innovation and Technology Commission and the Hong Kong Science and Technology Parks Corporation (HKSTP) was held successfully at Hong Kong Science Park. Under the theme of "From Collaborative Research to Real World Impact",  the summit aims to showcase the latest innovation and technology (I&T) developments and breakthroughs of the InnoHK, Hong Kong's leading role as a global research collaboration hub, and its strengths in commercialization and talent development.  

Professor Pengtao Liu, Managing Director of CTSCB, and Professor Gordon Dougan, Co-Director of CTSCB were invited to deliver a speech at the InnoHK Summit 2023.  Their captivating presentation shed light on our latest breakthrough achievement by leveraging the Expanded Potential Stem Cell (EPSC) technology and its applications in the medical, biotechnological and agricultural sectors. They also highlighted the immense potential of EPSC technology, which has accelerated the development of natural products in antiviral and anti-ageing, as well as drug screening technology.

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Photo shows the Secretary for Innovation, Technology and Industry, Professor Sun Dong (front row, 10th left); the Founding President of the Hong Kong Academy of Sciences and Chairman of the InnoHK Steering Committee, Professor Tsui Lap-chee (front row, ninth left); the Permanent Secretary for Innovation, Technology and Industry, Mr Eddie Mak (front row, 10th right); the Commissioner for Innovation and Technology, Mr Ivan Lee (front row, eighth left); and the Chief Executive Officer of the HKSTPC, Mr Albert Wong (front row, ninth right), Professor Pengtao Liu (front row, 3rd right), Professor Gordon Dougan (front row, 2nd right), Professor Bertie Göttgens (front row, 1st right) with directors of other InnoHK research centres and their non-local collaborators.

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Professor Liu and Professor Dougan shared insights at the InnoHK Summit 2023.

Newly Published:

November 10, 2023

Dr. Handi Cao, CTSCB Former Post-Doctoral Fellow published his paper in Life Science Alliance

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Newly Published:

August 23, 2023

Dr. Mingxi WENG,

Post-Doctoral Fellow at Dr. Ralf JAUCH 's lab published his paper in Science Advances

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June 12, 2023

Newly Published:

Shao XU, CTSCB Research Assistant published his paper in STAR Protocols, Cell Press

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June 2, 2023

Newly Published:

Yiming CHAO, CTSCB/HKU PhD student has just got her paper publish at Signal Transduction and Targeted Therapy, Nature

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April 28, 2023

CTSCB wins Silver Medal in the 48th International Exhibition of Inventions of Geneva

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Representing CTSCB, Prof. Fang Liu, Senior Scientific Director and Dr. Degong Ruan, Platform Leader, won a Silver Medalin the 48th International Exhibition of Inventions of Geneva.

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April 28, 2023

CTSCB wins Silver Medal in the 48th International Exhibition of Inventions of Geneva

Leading by Prof. Pengtao Liu, Managing Director of CTSCB, the human Expanded Potential Stem Cells (hEPSCs) developed for anti-virus drug development help to generate trophoblast stem cells (TSCs) and syncytiotrophoblasts (STBs), which express high levels of SARS-CoV-2 host factors and are highly susceptible to the viral infection. Remarkably, the infected eSTBs are 1,000 times more sensitive to antiviral drugs, making the TSC-STB platform a more ideal human cell source for viral production and performing antiviral discovery, including SARS-CoV-2, MERS, their variants, and the FDA approved anti-virus drugs and natural products.

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April 28, 2023 - Leading by Prof. Pengtao Liu, Managing Director of CTSCB, the human Expanded Potential Stem Cells (hEPSCs) developed for anti-virus drug development help to generate trophoblast stem cells (TSCs) and syncytiotrophoblasts (STBs), which express high levels of SARS-CoV-2 host factors and are highly susceptible to the viral infection. Remarkably, the infected eSTBs are 1,000 times more sensitive to antiviral drugs, making the TSC-STB platform a more ideal human cell source for viral production and performing antiviral discovery, including SARS-CoV-2, MERS, their variants, and the FDA approved anti-virus drugs and natural products.

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From Left to Right: Professor Fang Liu , CTSCB Senior Scientific Director, and Dr. Degong Ruan, Platform Leader

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Professor Liu briefing about anti-viral discovery to guests

January 12, 2023

Newly published:

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Dr JAUCH, Ralf from CTSCB & HKU published a paper titled "The homeodomain of Oct4 is a dimeric binder of methylated CpG elements"

January 9, 2023

US National Academy of Medicine
Health Longevity Catalyst Award (Hong Kong) 2022

Congratulations to Professor Pengtao Liu and his team for being awarded the United States National Academy of Medicine Healthy Longevity Catalysts Awards (Hong Kong) 2022 in the Healthy Longevity Global Competition.

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December 20, 2022

Newly published: Cell Reports Medicine

Scientists from CTSCB & HKU published a paper titled "Human Early Syncytiotrophoblasts are Highly Susceptible to SARS-CoV-2 Infection"

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Setpember 28, 2022

CTSCB speaks in ISTIF of Boao Forum

The first Hong Kong session of the International Science, Technology and Innovation Forum of Boao Forum for Asia is held at Hong Kong Science and Technology Park

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September 22, 2022

HKU Vice-Chancellor visits CTSCB

Professor Xiang ZHANG, Vice-Chancellor of The University of Hong Kong, sends his full support to InnoHK Centres by visiting CTSCB and others

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September 22nd, 2022 - Professor Xiang Zhang, the Vice-Chancellor of The University of Hong Kong (HKU), visited Centre for Translational Stem Cell Biology (CTSCB) and met with the fellow young scientists. During the visit, Professor Pengtao Liu CTSCB’s Managing Director, alongside with Professor Chak-Sing Lau, the Dean of Medicine at the HKU and CTSCB Programme leader, showcased the translational research plans on Expanded Potential Stem Cells (EPSCs) to Professor Zhang.

From Left to Right: Dr. Guocheng LAN (Principal Researcher, CTSCB), Professor Anderson SHUM (Managing Director, ABIC), Professor Chak-Sing LAU (Dean of Faculty of Medicine, HKU & Programme Leader, CTSCB), Professor Xiang ZHANG (Vice-Chancellor, HKU), Professor Pengtao LIU (Managing Director, CTSCB), Professor Fang LIU (Senior Scientific Director, CTSCB), Ms Sara LO (Acting Chief Operation Officer, HKU Innovation Holdings)

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Professor Liu briefing about EPSC works in CTSCB laboratory

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Presenting translational ideas in CTSCB Meeting Room

September 19, 2022

CTSCB showcases in RTHK I&T Programme

RTHK invites CTSCB to showcase in a 3-min TV programme, "I&T New Era 創科新里程"

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September 19th, 2022 – Centre for Translational Stem Cell Biology (CTSCB) is[DRL1] [MK2]  invited to showcase in a 3-min TV programme produced by Radio Television Hong Kong (RTHK – 香港電台), “I&T New Era 創科新里程”.

While CTSCB’s Managing Director Professor Pengtao Liu and Principal Investigator, Dr. Sau-Fong Vera Chan,were interviewed, a group of CTSCB researchers also participated in the video-shooting by conducting experiments with their unique skillsets.

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Dr. Chang MING, CTSCB Post-Doctoral Fellow, working on Neon Transfection System

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Dr. Vera CHAN talking about CTSCB’s strategies in Regenerative Medicine

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Professor Pengtao LIU introducing Expanded Potential Stem Cells (EPSCs)

August 31, 2022

Summer Internship @ CTSCB

CTSCB hosted 4 Summer Interns this year, concluding a fruitful Summer for these future young scientists

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August 31st, 2022 – A group of four students has completed their Summer Internship programme in Centre for Translational Stem Cell Biology (CTSCB). Miss Ri Min TAN, a Year 4 undergraduate from HKU Faculty of Education, was invited to summarise her experience upon completion of this internship.

According to her, one thing she has learnt was to pay extra attention on experiments and apply that on planning, the internship has also allowed her to identify her own strengths and weaknesses. “I am grateful for the opportunity given. I believe all the skills learnt in CTSCB have better prepared me for my future research career,” says Ri Min. She decides to continue her research work in CTSCB as a Research Assistant.

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From Left to Right:  Shao XU (Research Assistant), Ri Min TAN (Summer Intern), Tracy LEUNG (Summer Intern), Prof. Fang LIU (Senior Scientific Director, Prof. Pengtao LIU (Managing Director)

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"Having all supportive colleagues working together allowed me to adjust to a new and fast-paced working environment

August 3, 2022

Shanghai Pharmaceuticals Visit

Shanghai Pharmaceuticals is looking for business collaborations in Hong Kong, where CTSCB is invited to present stem cell translational ideas for potential investment

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August 3rd, 2022 – Shanghai Pharmaceuticals arranged a visit to Hong Kong Science and Technology Park seeking for business collaboration with InnoHK centres. Centre for Translational Stem Cell Biology (CTSCB) was honorably chosen to be one of the presenters on the day to pitch our business to the senior management at Shanghai Pharmaceuticals.

The leaders expressed great interest on CTSCB’s research projects and gave multiple constructive feedback and professional advice to the potential business development. CTSCB will anticipate cooperation with Shanghai Pharmaceuticals to promote biomedical and healthcare development in Hong Kong.   

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Professor Fang LIU, CTSCB Senior Scientific Director, presenting potential EPSCs technology development to senior management of Shanghai Pharmaceuticals

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Group Photo with senior management members of CTSCB and Shanghai Pharmaceuticals

June 23, 2022

HKUSU Biological Sciences Society Visits for Industrial Insight

The HKUSU Society gains a brief industrial insight and experimental experience in stem cell biology, anticipates to explore further in such field

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June 23rd, 2022 – A group of 20 undergraduate students ranging from Year 1 to Year 4, from Biological Sciences Society from the HKU Student Union, visited Centre for Translational Stem Cell Biology (CTSCB) for a half-day excursion for an opportunity to gain valuable industry exposure and learn all about stem cell biology. While Prof. Fang LIU, the CTSCB Senior Scientific Director, gave a briefing, Prof. Pengtao Liu, CTSCB Managing Director, also expressed his warmest welcome to all future young scientists.

Students participated in three arranged experiments, and they are thrilled to have the opportunity to operate actual experimental tools as the wet lab practical courses at the HKU have been suspended due to the pandemic.

Based on the experience, CTSBC are informed that most of the students are interested to work as an intern, we welcome applications starting from next March annually.  

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HKUSU Biological Sciences Society taking group photo in front of CTSCB

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Ms Yuqing ZHAI, CTSCB Research Assistant, Demonstrating the operation of pipette

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Dr. Xueyan LIU, CTSCB Post-Doctoral Fellow, explaining how to correctly use a microscope to view the stem cell

May 25, 2022

InnoHK Launches to Promote Innovation and Technology

CTSCB proudly to be one of the innovative members of Health@InnoHK, fully funded by Innovation and Technology Commission

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May 2, 2022

Cancer Immunotherapy Developers in Asia Explore Diverse Approaches

Novel concepts include intracellular-antigen-binding antibodies, light-activated drugs, antiviral T cells, and PD-1-based DNA vaccines

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(Before 2020)

What one of China’s most prestigious medical research centres’ arrival in Hong Kong could do for local innovation

Local scientists say arrival of the Guangzhou Institutes of Biomedicine and Health at city’s Science Park will bring much-needed staff and funding for vital stem cell research.

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