Publication

  • Yang J, Ryan DJ, Wang W… Lu L, Liu P. (2017). Establishment in Culture of Mouse Expanded Potential Stem Cells. Nature, 550 (7676): 393-397. http://dx.doi.org/0.1038/nature24052
  • Sugimura R, Jha DK, Han A… Doulatov S, Daley GQ. (2017) Haematopoietic Stem and Progenitor Cells from Human Pluripotent Stem Cells. Nature 545 (7655): 432–438. https://doi.org/10.1038/nature22370
  • Veerapandian V, Ackermann JO, Srivastava Y… Yang X, Jauch R. (2018) Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing. Stem Cell Reports 11: 593-606. https://doi.org/10.1016/j.stemcr.2018.07.002
  • Ibarra-Soria X, Jawaid W, Pijuan-Sala B… Göttgens B*, Marioni JC*. (2018) Defining murine organogenesis at single-cell resolution reveals a role for the leukotriene pathway in regulating blood progenitor formation. Nat Cell Biol. 20(2): 127-134. (*Corresponding author) https://doi.org/10.1038/s41556-017-0013-z
  • Gao X, Nowak-Imialek M, Chen X… Niemann H, Liu P. (2019) Establishment of human and pig expanded potential stem cells uncovers conserved signaling requirements. Nature Cell Biology, 21(6): 687-699. http://dx.doi.org/10.1038/s41556-019-0333-2
  • Pijuan-Sala B, Gtiffiths JA, Guibentif C… Marioni JC, Göttgens B. (2019) A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566(7745) 490-495. https://doi.org/10.1038/s41586-019-0933-9
  • Huang R, Huang Y, Guo Y… Lu M, Li T. (2019) Systematic characterization and prediction of post-translational modification cross-talk between proteins. Bioinformatics 35 (15): 2626-2633. http://dx.doi.org/10.1093/bioinformatics/bty1033
  • Chen ACH, Peng Q, Fong SW, Yeung WSB, Lee YL. (2020) Sirt1 is regulated by miR-135a and involved in DNA damage repair during mouse cellular reprogramming. Aging (Albany NY) 12(8): 7431-7447. https://doi.org/10.18632/aging.103090

Publication

  • Yu Y, Tsang JC, Wang C… Dougan G, Liu P. (2016) Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway. Nature 29 (539): 102-106. https://doi.org/10.1038/nature20105
  • CY Tam, WMM Li, YP Gao… CS Lau and VSF Chan. (2017) Human CLEC16A regulates autophagy through modulating mTOR activity. Experimental Cell Research 352: 304-312.  https://doi.org/10.1016/j.yexcr.2017.02.017 
  • Lee JC, Biasci D, Roberts R… Mansfield  Parkes M and Smith KGC. (2017) Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease. Nat Genet 49(2), 262-268.  https://doi.org/10.1038/ng.3755 
  • Yang W, Garrett L, Feng D… Yang Y, Gao B. (2017) Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development. Cell Res 27 (12): 1466-1484.  https://doi.org/10.1038/cr.2017.127 
  • IKY Lam, JX Chow, CS Lau, VSF Chan. (2018) MicroRNA-mediated immune regulation in rheumatic diseases. Cancer Lett 9 (431): 201-212.  http://dx.doi.org/10.1016/j.canlet.2018.05.044  
  • Forbester JL, Lees EA, Goulding D… Powrie F, Dougan G. (2018) Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells. Proc Natl Acad Sci USA 115: 10118-10123. https://doi.org/10.1073/pnas.1811866115
  • Gao B, Ajima R, Yang W… Yamaguchi TP, Yang Y. (2018) Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgfsignaling in planar cell polarity. Development 145 (8). https://doi.org/10.1242/dev.163824
  • Li PH, Wong WWY, Leung ENY, Lau CS, Au E. (2020) Novel mutations identified in the first Chinese pedigree of complete C6 deficiency. Clin Transl Immunology 9(7): e1148. https://doi.org/10.1002/cti2.1148 
  • Stewart BJ, Ferdinand JR, Clatworthy MR. (2020) Using single-cell technologies to map the human immune system – implications for nephrology. Nat Rev Nephrol. 16(2): 112-128. https://doi.org/10.1038/s41581-019-0227-3
  • Duque-Correa MA, Maizels RM, Grencis RK, Berriman M. (2020) Organoids - New Models for Host-Helminth Interactions. Trends Parasitol 36(2): 170-181. https://doi.org/10.1016/j.pt.2019.10.013

Official Collaborated with:

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March 8, 2024

An innovative method to generate brain stem cells for age-related diseases

Congratulations to Professor Ralf Jauch and his team for developing an innovative method to transform blood and skin cells into neural stem cell. This achievement overcomes the limitations of current stem cell research techniques while opening up new possibilities for studying and working towards treatments for age-related diseases.

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InnoHK Summit 2023

December 6, 2023

Professor Pengtao Liu, Managing Director of CTSCB, and Professor Gordon Dougan, Co-Director of CTSCB were invited to deliver a speech at the InnoHK Summit 2023. 

World

December 6 - The InnoHK Summit 2023, organized by the Innovation and Technology Commission and the Hong Kong Science and Technology Parks Corporation (HKSTP) was held successfully at Hong Kong Science Park. Under the theme of "From Collaborative Research to Real World Impact",  the summit aims to showcase the latest innovation and technology (I&T) developments and breakthroughs of the InnoHK, Hong Kong's leading role as a global research collaboration hub, and its strengths in commercialization and talent development.  

Professor Pengtao Liu, Managing Director of CTSCB, and Professor Gordon Dougan, Co-Director of CTSCB were invited to deliver a speech at the InnoHK Summit 2023.  Their captivating presentation shed light on our latest breakthrough achievement by leveraging the Expanded Potential Stem Cell (EPSC) technology and its applications in the medical, biotechnological and agricultural sectors. They also highlighted the immense potential of EPSC technology, which has accelerated the development of natural products in antiviral and anti-ageing, as well as drug screening technology.

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Photo shows the Secretary for Innovation, Technology and Industry, Professor Sun Dong (front row, 10th left); the Founding President of the Hong Kong Academy of Sciences and Chairman of the InnoHK Steering Committee, Professor Tsui Lap-chee (front row, ninth left); the Permanent Secretary for Innovation, Technology and Industry, Mr Eddie Mak (front row, 10th right); the Commissioner for Innovation and Technology, Mr Ivan Lee (front row, eighth left); and the Chief Executive Officer of the HKSTPC, Mr Albert Wong (front row, ninth right), Professor Pengtao Liu (front row, 3rd right), Professor Gordon Dougan (front row, 2nd right), Professor Bertie Göttgens (front row, 1st right) with directors of other InnoHK research centres and their non-local collaborators.

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Professor Liu and Professor Dougan shared insights at the InnoHK Summit 2023.

Newly Published:

November 10, 2023

Dr. Handi Cao, CTSCB Former Post-Doctoral Fellow published his paper in Life Science Alliance

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Newly Published:

August 23, 2023

Dr. Mingxi WENG,

Post-Doctoral Fellow at Dr. Ralf JAUCH 's lab published his paper in Science Advances

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June 12, 2023

Newly Published:

Shao XU, CTSCB Research Assistant published his paper in STAR Protocols, Cell Press

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June 2, 2023

Newly Published:

Yiming CHAO, CTSCB/HKU PhD student has just got her paper publish at Signal Transduction and Targeted Therapy, Nature

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April 28, 2023

CTSCB wins Silver Medal in the 48th International Exhibition of Inventions of Geneva

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Representing CTSCB, Prof. Fang Liu, Senior Scientific Director and Dr. Degong Ruan, Platform Leader, won a Silver Medal in the 48th International Exhibition of Inventions of Geneva.

April 28, 2023

CTSCB wins Silver Medal in the 48th International Exhibition of Inventions of Geneva

Leading by Prof. Pengtao Liu, Managing Director of CTSCB, the human Expanded Potential Stem Cells (hEPSCs) developed for anti-virus drug development help to generate trophoblast stem cells (TSCs) and syncytiotrophoblasts (STBs), which express high levels of SARS-CoV-2 host factors and are highly susceptible to the viral infection. Remarkably, the infected eSTBs are 1,000 times more sensitive to antiviral drugs, making the TSC-STB platform a more ideal human cell source for viral production and performing antiviral discovery, including SARS-CoV-2, MERS, their variants, and the FDA approved anti-virus drugs and natural products.

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April 28, 2023 - Leading by Prof. Pengtao Liu, Managing Director of CTSCB, the human Expanded Potential Stem Cells (hEPSCs) developed for anti-virus drug development help to generate trophoblast stem cells (TSCs) and syncytiotrophoblasts (STBs), which express high levels of SARS-CoV-2 host factors and are highly susceptible to the viral infection. Remarkably, the infected eSTBs are 1,000 times more sensitive to antiviral drugs, making the TSC-STB platform a more ideal human cell source for viral production and performing antiviral discovery, including SARS-CoV-2, MERS, their variants, and the FDA approved anti-virus drugs and natural products.

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From Left to Right: Professor Fang Liu , CTSCB Senior Scientific Director, and Dr. Degong Ruan, Platform Leader

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Professor Liu briefing about anti-viral discovery to guests

January 12, 2023

Newly published:

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Dr JAUCH, Ralf from CTSCB & HKU published a paper titled "The homeodomain of Oct4 is a dimeric binder of methylated CpG elements"

January 9, 2023

US National Academy of Medicine
Health Longevity Catalyst Award (Hong Kong) 2022

Congratulations to Professor Pengtao Liu and his team for being awarded the United States National Academy of Medicine Healthy Longevity Catalysts Awards (Hong Kong) 2022 in the Healthy Longevity Global Competition.

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